The main goal of the ICE-QUEST project is to improve understanding of the role which ice sheets played in the past climate changes and will play in mid- and long-term future under the influence of natural and anthropogenic forcings. One of the focal points of ICE-QUEST research is the interrelation between internal dynamics of the ice sheets and orbital and greenhouse forcings and possibility of rapid climate changes. This problem is important both for the explanation of the past glacial-interglacial variations, and future contribution of the ice sheet and glaciers to sea level rise.